5-fluorouracil cream for Bowen’s Disease

Patient Information: Using 5-fluorouracil cream for Bowen’s Disease

What is Bowen’s Disease?
Bowen’s disease is a type of skin cancer that primarily affects the outermost layer of the skin. It often appears as a red, scaly patch that may be crusty or itchy. If left untreated, Bowen’s disease can progress to invasive squamous cell carcinoma. However, with appropriate treatment using 5-fluorouracil cream it can be effectively managed.

How Does it work?
5-fluorouracil cream is a topical chemotherapy cream that contains 5-fluorouracil. When applied to the skin, it works by selectively targeting and destroying abnormal cells, including those present in Bowen’s disease, while sparing healthy tissue.

Instructions:

1. Preparation: Cleanse the affected area with a gentle soap and water, then pat dry with a soft towel. Avoid using any other creams, lotions, or cosmetics on the treated area unless instructed otherwise.
2. Application: Apply a thin layer of Efudix cream to the affected area along with a 5mm margin using clean fingertips or a cotton swab.
3. Frequency: Your dermatologist will advise you on the frequency of application, typically once or twice daily. Follow their instructions closely to ensure optimal results.
   
4. Duration of Treatment: The duration of Efudix treatment can vary depending on the extent and severity of Bowen’s disease. Most treatment courses last between 3 to 6 weeks. It is essential to complete the full course of treatment as prescribed, even if the lesions appear to have resolved before the end of treatment.
   
5. Side Effects: Expect to experience redness, inflammation and mild crusting during Efudix treatment. These side effects typically peak around the second or third week of treatment and gradually subside after discontinuation. If you experience severe or persistent side effects, contact your dermatologist for guidance.
6. Sun Protection: While using Efudix and during the healing process, protect the treated areas from sun exposure by wearing protective clothing, wide-brimmed hats, and using broad-spectrum sunscreen with SPF 30 or higher.
7. Follow-up Appointments: Attend all scheduled follow-up appointments to monitor your progress, assess treatment response, and address any concerns or side effects.

While Efudix (5-fluorouracil) is an effective treatment for various skin conditions, including Bowen’s disease, it does carry certain risks and potential side effects. It’s essential to be aware of these risks before starting treatment. Common risks associated with the use of Efudix include:

1. Skin Irritation: Efudix often causes redness, inflammation, itching, burning, and stinging at the site of application. These symptoms are common and usually peak around the second or third week of treatment before gradually improving.
2. Crusting and Peeling: The treated area may develop crusts, scabs, or patches of dry, flaky skin. This is a normal part of the healing process and typically resolves after discontinuing treatment.
3. Pain and Discomfort: Some individuals may experience discomfort or pain, particularly in areas where the skin is thin or sensitive. This can occur during the application of Efudix or as a result of skin irritation.
4. Photosensitivity: Efudix can increase the skin’s sensitivity to sunlight, making it more prone to sunburn and damage. It is essential to protect the treated areas from sun exposure by wearing protective clothing and applying sunscreen with a high SPF rating.
5. Allergic Reactions: While rare, some people may experience allergic reactions to Efudix, characterised by rash, itching, swelling, or difficulty breathing. If you develop signs of an allergic reaction, discontinue use and seek medical attention immediately.
6. Secondary Infections: In some cases, Efudix treatment can lead to the development of secondary bacterial or fungal infections in the treated area. Watch for signs of infection, such as increased redness, warmth, swelling, or discharge, and notify your healthcare provider if you suspect an infection.
7. Eye Irritation: Avoid getting Efudix cream in your eyes, as it can cause irritation and discomfort. If accidental contact occurs, rinse thoroughly with water and seek medical advice if symptoms persist.
8. Systemic Absorption: Although rare, there is a risk of systemic absorption of Efudix, particularly if applied to large areas of the skin or used for an extended period. This can lead to systemic side effects, such as nausea, vomiting, diarrhoea, or bone marrow suppression.

For personal use only. Intended for the patients of Dr Anes Yang. Please refer to the disclaimer.